The most fuel efficient car of is the Honda Insight. It has a combined MPG of 52 and costs $1, per year to drive it. The most fuel efficient non-. Fuel Economy of Midsize Cars ; Compare ; Combined MPG combined. city/highway. MPG. City MPG city. Highway MPG highway. gals/ miles ; Not. Toyota Prius · 46 · 48, 45 · gal/ mi ; Toyota Corolla · 31 · 28, 37 · gal/ mi ; Toyota Corolla · 29 · 26, 35 · gal/ mi.
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